Mycophenolic acid derivatives from cultures of the mushroom Laetiporus sulphureu.
10.1016/S1875-5364(14)60104-7
- Author:
Qiong-Ying FAN
1
;
Xia YIN
2
,
3
;
Zheng-Hui LI
4
;
Yan LI
4
;
Ji-Kai LIU
4
;
Tao FENG
5
;
Bao-Hua ZHAO
6
Author Information
1. College of Life Science, Hebei Normal University, Shijiazhuang 050024, China.
2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China
3. University of Chinese Academy of Sciences, Beijing 100049, China.
4. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China.
5. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China. Electronic address: fengtao@mail.kib.ac.cn.
6. College of Life Science, Hebei Normal University, Shijiazhuang 050024, China. Electronic address: zhaobaohua86178@sohu.com.
- Publication Type:Journal Article
- Keywords:
Cytotoxicity;
Laetiporus sulphureus;
Mycophenolic acid derivatives
- MeSH:
Agaricales;
Biological Products;
chemistry;
isolation & purification;
pharmacology;
therapeutic use;
HL-60 Cells;
Humans;
MCF-7 Cells;
Molecular Structure;
Mycophenolic Acid;
analogs & derivatives;
chemistry;
isolation & purification;
Neoplasms;
drug therapy;
Phenols;
chemistry;
isolation & purification;
pharmacology;
therapeutic use;
Polyporales;
chemistry
- From:
Chinese Journal of Natural Medicines (English Ed.)
2014;12(9):685-688
- CountryChina
- Language:English
-
Abstract:
AIM:To investigate the chemical constituents of the cultures of Laetiporus sulphureus (Bull.) Murrill.
METHOD:Compounds were isolated and purified by various chromatographic techniques. The structure of the new compound was determined by interpretation of MS and 1D-, 2D-NMR spectroscopic data, while the known compounds were identified by comparison of their data with those reported.
RESULTS:Three mycophenolic acid derivatives, 6-((2E, 6E)-3, 7-dimethyldeca-2, 6-dienyl)-7-hydroxy-5-methoxy-4-methylphtanlan-1-one (1), 6-((2E, 6E)-3, 7, 11-trimethyldedoca-2, 6, 10-trienyl)-5, 7-dihydroxy-4-methylphtanlan-1-one (2), and 6-((2E, 6E)-3, 7, 11-trimethyldedoca-2, 6, 10-trienyl)-7-hydroxy-5-methoxy-4-methylphtanlan-1-one (3) were isolated.
CONCLUSION:Among them, compound 1 was new, and compound 2 exhibited moderate cytotoxicity against HL-60, SMMC-7721, A-549, and MCF-7 cells, with IC50 values of 39.1, 31.1, 27.4, and 35.7 μmol·L(-1), respectively.
