Antidepressant-like effect of essential oil of Perilla frutescens in a chronic, unpredictable, mild stress-induced depression model mice.
10.1016/S1875-5364(14)60115-1
- Author:
Wei-Wei JI
1
;
Rui-Peng LI
1
;
Meng LI
1
;
Shu-Yuan WANG
1
;
Xian ZHANG
2
;
Xing-Xing NIU
3
;
Wei LI
3
;
Lu YAN
3
;
Yang WANG
3
;
Qiang FU
4
;
Shi-Ping MA
5
Author Information
1. Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing 210009, China.
2. School of Sciences, China Pharmaceutical University, Nanjing 210009, China.
3. School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
4. Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing 210009, China. Electronic address: fuqiang0114@sina.com.
5. Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing 210009, China. Electronic address: spma@cpu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Anti-inflammation;
Antidepressant;
Chronic unpredictable mild stress;
Essential oil;
Perilla frutescens
- MeSH:
Animals;
Antidepressive Agents;
administration & dosage;
Behavior, Animal;
drug effects;
Chronic Disease;
therapy;
Cytokines;
blood;
Depression;
blood;
drug therapy;
physiopathology;
psychology;
Disease Models, Animal;
Humans;
Male;
Mice;
Mice, Inbred ICR;
Oils, Volatile;
administration & dosage;
Perilla frutescens;
chemistry;
Plant Oils;
administration & dosage;
Stress, Physiological;
drug effects
- From:
Chinese Journal of Natural Medicines (English Ed.)
2014;12(10):753-759
- CountryChina
- Language:English
-
Abstract:
Perilla frutescens (Perilla leaf), a garnishing vegetable in East Asian countries, as well as a plant-based medicine, has been used for centuries to treat various conditions, including depression. Several studies have demonstrated that the essential oil of P. frutescens (EOPF) attenuated the depressive-like behavior in mice. The present study was designed to test the anti-depressant effects of EOPF and the possible mechanisms in an chronic, unpredictable, mild stress (CUMS)-induced mouse model. With the exposure to stressor once daily for five consecutive weeks, EOPF (3, 6, and 9 mg·kg(-1)) and a positive control drug fluoxetine (20 mg·kg(-1)) were administered through gastric intubation to mice once daily for three consecutive weeks from the 3(rd) week. Open-field test, sucrose consumption test, tail suspension test (TST), and forced swimming test (FST) were used to evaluate the behavioral activity. The contents of 5-hydroxytryptamine (5-HT) and its metabolite, 5-hydroxyindoleacetic acid (5-HIAA), in mouse hippocampus were determined by HPLC-ECD. Serum interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF)-α levels were evaluated by enzyme-linked immunosorbent assay (ELISA). The results showed that CUMS significantly decreased the levels of 5-HT and 5-HIAA in the hippocampus, with an increase in plasma IL-6, IL-1β, and TNF-α levels. CUMS also reduced open-field activity, sucrose consumption, as well as increased immobility duration in FST and TST. EOPF administration could effectively reverse the alterations in the concentrations of 5-HT and 5-HIAA; reduce the IL-6, IL-1β, and TNF-α levels. Moreover, EOPF could effectively reverse alterations in immobility duration, sucrose consumption, and open-field activity. However, the effect was not dose-dependent. In conclusion, EOPF administration exhibited significant antidepressant-like effects in mice with CUMS-induced depression. The antidepressant activity of EOPF might be related to the relation between alteration of serotonergic responses and anti-inflammatory effects.
