A lignin glycoside and a nortriterpenoid from Kadsura coccinea.
10.1016/S1875-5364(14)60119-9
- Author:
Jae-Ho YEON
1
,
2
;
Liang CHENG
3
;
Quan-Quan HE
4
;
Ling-Yi KONG
5
Author Information
1. State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China
2. Amorepacific Shanghai R & I Center, Shanghai 201801, China.
3. State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 200040, China.
4. Amorepacific Shanghai R & I Center, Shanghai 201801, China.
5. State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China. Electronic address: cpu_lykong@126.com.
- Publication Type:Journal Article
- Keywords:
Kadsura coccinea;
Lignan glucoside;
Schisandraceae;
Triterpenoid
- MeSH:
Animals;
Cell Line;
Glycosides;
chemistry;
isolation & purification;
pharmacology;
Kadsura;
chemistry;
Lignin;
chemistry;
isolation & purification;
pharmacology;
Macrophages;
drug effects;
metabolism;
Magnetic Resonance Spectroscopy;
Mass Spectrometry;
Mice;
Molecular Structure;
Nitric Oxide;
metabolism;
Plant Extracts;
chemistry;
isolation & purification;
pharmacology;
Plant Roots;
chemistry
- From:
Chinese Journal of Natural Medicines (English Ed.)
2014;12(10):782-785
- CountryChina
- Language:English
-
Abstract:
AIM:To study the chemical constituents of the roots and stem bark of Kadsura coccinea.
METHOD:Compounds were isolated by column chromatography on silica gel and Sephadex LH-20, and finally purified by prep-HPLC. Their structures were elucidated by extensive spectroscopic methods, including 1D- and 2D-NMR, and HR-ESI-MS.
RESULTS:Two compounds were determined as (7'S,8'S,8R)-(8β,8'α)-dimethyl-4,4'-dihydroxy-5,3'-dimethoxy-5'-cyclolignan glucoside (1) and micrandiactone H (2), respectively.
CONCLUSION:Compunds 1 and 2 are new and neither showed inhibitory effects on nitric oxide (NO) production in lipopolysaccharide-induced RAW264.7 macrophages.
