Hypolipidemic activity of a hydroalcoholic extract of Cyperus scariosus Linn. root in guinea pigs fed with a high cholesterol diet.
10.1016/S1875-5364(14)60123-0
- Author:
Hiren M CHAWDA
1
;
Divyesh R MANDAVIA
2
;
Pravin H PARMAR
3
;
Seema N BAXI
2
;
Chandrabhanu R TRIPATHI
4
Author Information
1. Pacific Medical College & Hospital, Udaipur, Rajasthan, India. Electronic address: hiren_chawda1987@yahoo.co.in.
2. Government Medical College, Bhavnagar-364001, Gujarat, India.
3. Analytical Chemistry Division, Department of Chemistry, Maharaja Krishnakumarsinhji Bhavnagar University, Bhavnagar 364002, India.
4. Government Medical College, Bhavnagar-364001, Gujarat, India. Electronic address: cbrtripthi@yahoo.co.in.
- Publication Type:Journal Article
- Keywords:
Antioxidant activity;
Cyperus scariosus;
Dyslipidemia;
Statin
- MeSH:
Animals;
Cyperus;
Female;
Guinea Pigs;
Hypercholesterolemia;
drug therapy;
Hypolipidemic Agents;
pharmacology;
therapeutic use;
Kidney;
pathology;
Liver;
pathology;
Male;
Mice;
Plant Extracts;
pharmacology;
therapeutic use;
Plant Roots;
chemistry
- From:
Chinese Journal of Natural Medicines (English Ed.)
2014;12(11):819-826
- CountryChina
- Language:English
-
Abstract:
Lipid-lowering and antioxidant activities of a hydroalcoholic extract of Cyperus scariosus Linn. root (HCS) were evaluated in guinea pigs fed with a high cholesterol diet. Serum lipid profile (total cholesterol, triglycerides, LDL-C, VLDL-C, and HDL-C), atherogenic indices and serum enzymes (ALT, AST, ALP, LDH, and CK-MB) were performed in each group at 0 days and at the end of 60 days. Histological study of liver and kidney was done in groups 1, 2, 5, 6 and 7. The total phenolic and flavonoid content in HCS and its antioxidant activity were evaluated by the DPPH assay. Both doses of HCS decreased serum lipid profile and atherogenic indices (P < 0.05). HCS has lipid lowering, immunosuppressive and antioxidant properties, and mays have value in atherosclerosis prevention. The higher dose of HCS also reduced serum AST, ALP, and LDH levels and rosuvastatin increased AST and ALP levels (P < 0.05). Histology of the liver showed decreased lipid accumulation and improvement in hepatocytes in HCS-treated animals. The antioxidant activity of HCS may be responsible for its lipid lowering and cytoprotective action. HCS had significant lipid lowering and antioxidant activity, which; may be due to the phenolic compounds. HCS may be a safe and cost effective alternative to current statin therapy for patients with dyslipidaemia.
