Wheat peptides reduce oxidative stress and inhibit NO production through modulating μ-opioid receptor in a rat NSAID-induced stomach damage model.
10.1016/S1875-5364(15)60003-6
- Author:
Hong YIN
1
;
Hui-Zhen CAI
2
;
Shao-Kang WANG
1
;
Li-Gang YANG
1
;
Gui-Ju SUN
3
Author Information
1. Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China.
2. School of Public Health, Ningxia Medical University, Yinchuan 750004, China.
3. Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China. Electronic address: gjsun@seu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Oxidative stress;
Stomach damage;
Wheat peptides;
iNOS;
μ-Opioid receptor
- MeSH:
Animals;
Anti-Inflammatory Agents, Non-Steroidal;
adverse effects;
Antioxidants;
pharmacology;
Aspirin;
adverse effects;
Gastric Mucosa;
drug effects;
Gene Expression;
Glutathione Peroxidase;
drug effects;
Indomethacin;
adverse effects;
Male;
Nitric Oxide;
biosynthesis;
Nitric Oxide Synthase;
chemical synthesis;
Oxidation-Reduction;
Oxidative Stress;
drug effects;
Plant Proteins;
pharmacology;
RNA, Messenger;
genetics;
Rats;
Rats, Sprague-Dawley;
Receptors, Opioid, mu;
drug effects;
Stomach;
drug effects;
Superoxide Dismutase;
drug effects;
Triticum;
chemistry
- From:
Chinese Journal of Natural Medicines (English Ed.)
2015;13(1):22-29
- CountryChina
- Language:English
-
Abstract:
Non-steroidal anti-inflammatory drugs (NSAIDs) induce tissue damage and oxidative stress in animal models of stomach damage. In the present study, the protective effects of wheat peptides were evaluated in a NSAID-induced stomach damage model in rats. Different doses of wheat peptides or distilled water were administered daily by gavage for 30 days before the rat stomach damage model was established by administration of NSAIDs (aspirin and indomethacin) into the digestive tract twice. The treatment of wheat peptides decreased the NSAID-induced gastric epithelial cell degeneration and oxidative stress and NO levels in the rats. Wheat peptides significantly increased the superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities and decreased iNOS activity in stomach. The mRNA expression level of μ-opioid receptor was significantly decreased in wheat peptides-treated rats than that in in the control rats. The results suggest that NSAID drugs induced stomach damage in rats, wchih can be prevented by wheat peptides. The mechanisms for the protective effects were most likely through reducing NSAID-induced oxidative stress.
