Siderochelins with anti-mycobacterial activity from Amycolatopsis sp. LZ149.
10.1016/S1875-5364(15)60009-7
- Author:
Chun-Hua LU
1
;
Fang-Wen YE
2
;
Yue-Mao SHEN
3
,
4
Author Information
1. Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China. Electronic address: ahua0966@sdu.edu.cn.
2. School of Life Sciences, Xiamen University, Xiamen 361005, china.
3. Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
4. School of Life Sciences, Xiamen University, Xiamen 361005, china.
- Publication Type:Journal Article
- Keywords:
Amycolatopsis sp. LZ149;
Bioassay-guided;
Mycobacterium smegmatis;
Siderochelin;
X-ray single crystal diffraction
- MeSH:
Actinobacteria;
chemistry;
Anti-Infective Agents;
pharmacology;
Dihydropyridines;
isolation & purification;
Magnetic Resonance Spectroscopy;
Microbial Sensitivity Tests;
Molecular Structure;
Mycobacterium smegmatis;
drug effects
- From:
Chinese Journal of Natural Medicines (English Ed.)
2015;13(1):69-72
- CountryChina
- Language:English
-
Abstract:
Three new compounds, namely siderochelins D (2), E (3), and F (4), together with one known siderochelin A (1), were isolated from Amycolatopsis sp. LZ149 and elucidated by spectroscopic analyses including1D- and 2D-NMR and X-ray single crystal diffraction. Compounds 1-3 showed antibacterial activity against Mycobacterium smegmatis.
