Cycloartenol triterpenoid saponins from Cimicifuga simplex (Ranunculaceae) and their biological effects.
10.1016/S1875-5364(15)60011-5
- Author:
Lun WU
1
;
Zhi-Li CHEN
1
;
Yang SU
2
;
Qiu-Hong WANG
1
;
Hai-Xue KUANG
3
Author Information
1. Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, 150040 Harbin, China.
2. Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, 150040 Harbin, China. Electronic address: suyanggo@163.com.
3. Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, 150040 Harbin, China. Electronic address: hxkuang@hotmail.com.
- Publication Type:Journal Article
- Keywords:
Biological effects;
Cimicifuga simplex;
Cycloartenol triterpenoid saponins;
Ranunculaceae
- MeSH:
Animals;
Cimicifuga;
chemistry;
Humans;
Phytosterols;
chemistry;
isolation & purification;
pharmacology;
Plant Extracts;
chemistry;
isolation & purification;
pharmacology;
Saponins;
chemistry;
isolation & purification;
pharmacology;
Triterpenes;
chemistry;
isolation & purification;
pharmacology
- From:
Chinese Journal of Natural Medicines (English Ed.)
2015;13(2):81-89
- CountryChina
- Language:English
-
Abstract:
The constituents of Cimicifuga plants have been extensively investigated, and the principal metabolites are 9,19-cyclolanostane triterpenoid glycosides, which are distributed widely in Cimicifuga plants, but not in other members of the Ranunculaceae family, and are considered to be characteristics of the Cimicifuga genus. This type of triterpenoid glycoside possesses several important biological activities. More than 120 cycloartane triterpene glycosides have been isolated from Cimicifuga simplex Wormsk. The aim of this review article is to summarize all the major findings based on the available scientific literatures on C. simplex, with a focus on the identified 9,19-cyclolanostane triterpenoid glycosides. Biological studies of cycloartane triterpene glycosides from Cimicifuga spp. are also discussed.
