Optimization of the processing technology of Fructus Arctii by response surface methodology.
10.1016/S1875-5364(15)30008-X
- Author:
Qi-Di LIU
1
,
2
,
3
;
Kun-Ming QIN
1
,
2
,
3
;
Bao-Jia SHEN
4
;
Hao CAI
1
,
3
;
Bao-Chang CAI
1
,
2
,
5
Author Information
1. Engineering Center of State Ministry of Education for Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210023, China
2. Nanjing Haichang Chinese Medicine Group Co, Ltd, Nanjing 210061, China
3. Key Laboratory of State Administration of TCM for Standardization of Chinese Medicine Processing, Nanjing 210023, China.
4. Engineering Center of State Ministry of Education for Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210023, China.
5. Key Laboratory of State Administration of TCM for Standardization of Chinese Medicine Processing, Nanjing 210023, China. Electronic address: bccai@126.com.
- Publication Type:Journal Article
- Keywords:
Fructus Arctii;
Processing technology;
Response surface methodology (RSM)
- MeSH:
Arctium;
chemistry;
Chemistry, Pharmaceutical;
methods;
Chlorogenic Acid;
analysis;
Chromatography, High Pressure Liquid;
Drugs, Chinese Herbal;
chemistry;
Furans;
analysis;
Glucosides;
analysis;
Hot Temperature;
Lignans;
analysis;
Surface Properties;
Technology, Pharmaceutical;
methods
- From:
Chinese Journal of Natural Medicines (English Ed.)
2015;13(3):222-231
- CountryChina
- Language:English
-
Abstract:
The present study was designed to optimize the processing of Fructus Arctii by response surface methodology (RSM). Based on single factor studies, a three-variable, three-level Box-Behnken design (BBD) was used to monitor the effects of independent variables, including processing temperature and time, on the dependent variables. Response surfaces and contour plots of the contents of total lignans, chlorogenic acid, arctiin, and arctigenin were obtained through ultraviolet and visible (UV-Vis) monitoring and high performance liquid chromatography (HPLC). Fructus Arctii should be processed under heating in a pot at 311 °C, medicine at 119 °C for 123s with flipping frequently. The experimental values under the optimized processing technology were consistent with the predicted values. In conclusion, RSM is an effective method to optimize the processing of traditional Chinese medicine (TCM).
