Structural elucidation of two new megastigmane glycosides from the leaves of Aquilaria sinensis.
10.1016/S1875-5364(15)30016-9
- Author:
Jian SUN
1
;
Fang XIA
2
;
Shu WANG
1
;
Ke-Yuan WANG
3
;
Jin-Ming CHEN
3
;
Peng-Fei TU
4
Author Information
1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China.
2. TaiJi Pharmaceutical Research Institute, Chongqing 400118, China.
3. Guangdong Junyuan Pharmaceutical Co., Ltd., Guangzhou 525432, China.
4. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China. Electronic address: pengfeitu@vip.163.com.
- Publication Type:Journal Article
- Keywords:
Aquilaria sinensis (Lour.) Gilg;
Megstigmane glucosides
- MeSH:
Chromatography, Liquid;
Cucurbitacins;
chemistry;
Cyclohexanones;
chemistry;
Glucosides;
chemistry;
isolation & purification;
Magnetic Resonance Spectroscopy;
Norisoprenoids;
chemistry;
isolation & purification;
Plant Leaves;
chemistry;
Thymelaeaceae;
chemistry
- From:
Chinese Journal of Natural Medicines (English Ed.)
2015;13(4):290-294
- CountryChina
- Language:English
-
Abstract:
The present study was designed to determine the chemical constituents and identify new components of the leaves of Aquilaria sinensis (Lour.) Gilg. The compounds were isolated and purified by repeated silica gel, Sephadex LH-20, and ODS column chromatography and their structures were elucidated by NMR and HR-ESI-MS spectrometry. Eight megastigmane glycosides and two cucurbitacins were isolated and identified as (9S) megastigma-4,7-diene-2,3,9-triol 9-O-β-D-glucopyranoside (1), (9S) megastigma-4(13),7-diene-3,6,9-triol 9-O-β-D-glucopyranoside (2), macarangloside D (3), corchoionoside C (4), staphylionoside H (5), (+) 3-oxo-α-ionol-β-D-glucopyranoside (6), (-) 3-oxo-α-ionol-β-D-glucopyranoside (7), citroside B (8), 2-O-β-D-glucopyranosyl cucurbitacin I (9), bryoamaride (10). Compounds 1 and 2 were newly identified megstigmane glucosides and reported from this genus for the first time.
