Two new conjugated ketonic fatty acids from the stem bark of Juglans mandshurica.
10.1016/S1875-5364(15)30018-2
- Author:
Da-Lei YAO
1
;
Chang-Hao ZHANG
1
;
Ren LI
2
;
Jie LUO
1
;
Mei JIN
3
,
4
;
Jin-Hua PIAO
1
;
Ming-Shan ZHENG
1
;
Jiong-Mo CUI
1
;
Jong Keun SON
5
;
Gao LI
6
Author Information
1. Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji 133002, China.
2. Department of Pharmacy, Yanbian University Hospital, Yanji 133000, China.
3. Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji 133002, China
4. Department of Pharmacy, Yanbian University Hospital, Yanji 133000, China.
5. College of Pharmacy, Yeungnam University, Gyongsan 712-749, Korea.
6. Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji 133002, China. Electronic address: gli@ybu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Conjugated ketonic fatty acid;
Juglandaceae;
Juglans mandshurica
- MeSH:
Fatty Acids, Unsaturated;
chemistry;
isolation & purification;
Juglans;
chemistry;
Plant Bark;
chemistry;
Spectrum Analysis
- From:
Chinese Journal of Natural Medicines (English Ed.)
2015;13(4):299-302
- CountryChina
- Language:English
-
Abstract:
The present study was designed to isolate and characterize novel chemical constituents of the stem bark of Juglans mandshurica Maxim. (Juglandaceae). The chemical constituents were isolated and purified by various chromatographic techniques. The structures of the compounds were elucidated on the basis of spectral data (1D and 2D NMR, HR-ESI-MS, CD, UV, and IR) and by the comparisons of spectroscopic data with the reported values in the literatures. Two long chain polyunsaturated fatty acids (1 and 2) were obtained and identified as (S)-(8E,10E)-12-hydroxy-7-oxo-8,10-octadecadienoic acid (1) and (S)-(8E, 10E)-12-hydroxy-7-oxo-8,10-octadecadienoic acid methyl ester (2). To the best of our knowledge, this is the first report on the isolation and structural elucidation of the two new conjugated ketonic fatty acids from this genus.
