Synthesis and cytotoxicity of longistylin C derivatives.
10.1016/S1875-5364(15)30021-2
- Author:
Yan SHAN
1
;
Ting HONG
1
;
Yan-Fei WANG
1
;
Nen-Ling ZHANG
2
;
Bo YU
1
;
Yu LU
3
;
Sheng-Xiang QIU
4
Author Information
1. Sino-German Joint Research Institute, Nanchang University, Nanchang 330047, China.
2. South China Botanical Garden, the Chinese Academy of Science, Guangzhou 510560, China.
3. Sino-German Joint Research Institute, Nanchang University, Nanchang 330047, China. Electronic address: luyzsu@hotmail.com.
4. South China Botanical Garden, the Chinese Academy of Science, Guangzhou 510560, China. Electronic address: sxqiu@scbg.ac.cn.
- Publication Type:Journal Article
- Keywords:
Cytotoxicity;
LongistylinC derivatives;
Synthesis
- MeSH:
Antineoplastic Agents;
chemical synthesis;
pharmacology;
Cell Line, Tumor;
Drug Screening Assays, Antitumor;
Humans;
Structure-Activity Relationship
- From:
Chinese Journal of Natural Medicines (English Ed.)
2015;13(4):311-315
- CountryChina
- Language:English
-
Abstract:
The present study was designed to identify potent anti-tumor compounds from a series of new longistylin C derivatives. Ten longistylin C derivatives were synthesized and their structures were confirmed by (1)H NMR, MS, and elemental analyses. Their cytotoxicity in vitro against three human cancer cell lines (A549, HepG2, and MCF-7) were evaluated by the MTT assay. Among these compounds, DT-6 and DT-9 displayed much better cytotoxicity against A549, HepG2, and MCF-7 cells, DT-1 exhibited selective cytotoxicity against HepG2, and the structure-activity relationships were investigated. In conclusion, Compounds DT-6 and DT-9 may serve as potential lead compounds for the discovery of new anti-cancer drugs.
