Three new triterpenoids isolated from the aerial parts of Ilex cornuta and protective effects against HO-induced myocardial cell injury.
10.1016/S1875-5364(17)30027-4
- Author:
Shan-Shan LI
1
,
2
;
Yan-Li LIU
3
;
Qiong-Ming XU
4
;
Chen-Mei MAO
5
;
Shi-Lin YANG
3
Author Information
1. Children's Hospital of Soochow University, Suzhou 215003, China
2. College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.
3. College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.
4. College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China. Electronic address: xuqiongming@suda.edu.cn.
5. Children's Hospital of Soochow University, Suzhou 215003, China. Electronic address: maocm68@163.com.
- Publication Type:Journal Article
- Keywords:
Aquifoliaceae;
Cardiomyocytes Oxidative injury;
Ilex cornuta;
Triterpenoids
- MeSH:
Animals;
Biphenyl Compounds;
metabolism;
Cardiovascular Agents;
chemistry;
isolation & purification;
pharmacology;
Hydrogen Peroxide;
metabolism;
Ilex;
chemistry;
Molecular Structure;
Myocardium;
cytology;
pathology;
Myocytes, Cardiac;
drug effects;
Picrates;
metabolism;
Plant Components, Aerial;
chemistry;
Plant Extracts;
chemistry;
pharmacology;
Rats;
Triterpenes;
chemistry;
isolation & purification;
pharmacology
- From:
Chinese Journal of Natural Medicines (English Ed.)
2017;15(2):115-120
- CountryChina
- Language:English
-
Abstract:
In the present study, three new triterpenoids, 23-hydroxyurs-12, 18-dien-28-oic acid 3β-O-α-L-arabinopyranoside (1), 23-hydroxyurs-12, 18-dien-28-oic acid 3β-O-β-D-glucuronopyranoside-6-O-methyl ester (2), and urs-12, 18-dien-28-oic acid 3β-O-β-D-glucuronopyranoside-6-O-methyl ester (3), and a known triterpenoid, 3β-hydroxy-urs-2, 18-dien-28-oic acid (4, randialic acid B), were isolated from the aerial parts of Ilex cornuta. Their structures were identified by the spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, and 1D and 2D NMR) and chemical reactions. Compound 4 showed significant cell-protective effects against HO-induced H9c2 cardiomyocyte injury. Compounds 1-4 did not show any significant DPPH radical scavenging activity.
