Antihyperglycemic, antihyperlipidemic and antioxidant effects of standard ethanol extract of Bombax ceiba leaves in high-fat-diet- and streptozotocin-induced Type 2 diabetic rats.
10.1016/S1875-5364(17)30033-X
- Author:
Guang-Kai XU
1
;
Xiao-Ying QIN
1
;
Guo-Kai WANG
2
;
Guo-Yong XIE
1
;
Xu-Sen LI
1
;
Chen-Yu SUN
1
;
Bao-Lin LIU
3
;
Min-Jian QIN
4
Author Information
1. State Key Laboratory of Natural Medicines, Department of Resources Science of Traditional Chinese Medicines, China Pharmaceutical University, Nanjing 210009, China.
2. Anhui Key Laboratory of Modernized Chinese Materia Medica, Anhui University of Traditional Chinese Medicine, Hefei 230012, China.
3. Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing 210009, China. Electronic address: zhongyao440@163.com.
4. State Key Laboratory of Natural Medicines, Department of Resources Science of Traditional Chinese Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address: minjianqin@163.com.
- Publication Type:Journal Article
- Keywords:
Antihyperglycemic;
Antihyperlipidemic;
Antioxidant;
Bombax ceiba;
Type 2 diabetic mellitus
- MeSH:
Animals;
Antioxidants;
administration & dosage;
chemistry;
isolation & purification;
Blood Glucose;
metabolism;
Bombax;
chemistry;
Diabetes Mellitus, Type 2;
drug therapy;
metabolism;
Humans;
Hypoglycemic Agents;
administration & dosage;
chemistry;
isolation & purification;
Hypolipidemic Agents;
administration & dosage;
chemistry;
isolation & purification;
Male;
Plant Extracts;
administration & dosage;
chemistry;
isolation & purification;
Plant Leaves;
chemistry;
Rats;
Rats, Sprague-Dawley
- From:
Chinese Journal of Natural Medicines (English Ed.)
2017;15(3):168-177
- CountryChina
- Language:English
-
Abstract:
The present study aimed at exploring the therapeutic potential of standard extract of Bombax ceiba L. leaves (BCE) in type 2 diabetic mellitus (T2DM). Oral administration of BCE at doses of 70, 140, and 280 mg·kg, to the normal rats and the high-fat-diet- and streptozotocin-induced T2DM rats were carried out. Effects of BCE on blood glucose, body weight, and a range of serum biochemical parameters were tested, and histopathological observation of pancreatic tissues was also performed. HPLC-ESI-Q/TOF-MS/MS analysis indicated that the chemical composition of BCE mainly contained mangiferin, isoorientin, vitexin, isomangiferin, isovitexin, quercetin hexoside, 2'-trans-O-cumaroyl mangiferin, and nigricanside. BCE caused a significant decrease in the concentrations of fasting blood glucose, glycosylated hemoglobin, total cholesterol, triglyceride, low density lipoprotein-cholesterol, serum insulin, and malondialdehyde, and increases in oral glucose tolerance, high density lipoprotein-cholesterol, and superoxide dismutase in the T2DM model rats. Moreover, considerable pancreatic β-cells protection effect and stimulation of insulin secretion from the remaining pancreatic β-cells could be observed after BCE treatment. The results indicated that BCE exhibited an excellent hypoglycemic activity, and alleviated dyslipidemia which is associated with T2DM. Antioxidant activity and protecting pancreatic β-cells are the possible mechanisms involved in anti-diabetic activity of BCE.
