Oral administration of red ginseng powder fermented with probiotic alleviates the severity of dextran-sulfate sodium-induced colitis in a mouse model.
10.1016/S1875-5364(17)30035-3
- Author:
Sun-Hee JANG
1
;
Jisang PARK
2
;
Sae-Hae KIM
3
,
4
;
Kyung-Min CHOI
5
;
Eun-Sil KO
5
;
Jeong-Dan CHA
5
;
Young-Ran LEE
6
;
Hyonseok JANG
7
;
Yong-Suk JANG
3
,
8
Author Information
1. Department of Molecular Biology and Institute for Molecular Biology and Genetics, Chonbuk National University, Jeonju 54896, Korea.
2. Department of Bioactive Material Sciences and Research Center of Bioactive Materials, Chonbuk National University, Jeonju 54896, Korea.
3. Department of Molecular Biology and Institute for Molecular Biology and Genetics, Chonbuk National University, Jeonju 54896, Korea
4. Department of Bioactive Material Sciences and Research Center of Bioactive Materials, Chonbuk National University, Jeonju 54896, Korea.
5. Department of Efficacy Research, Institute of Jinan Red Ginseng, Jinan 55442, Korea.
6. Department of Mathematics, Sogang University, Seoul 04107, Korea.
7. Department of Oral Maxillofacial Surgery, Korea University Ansan Hospital, Ansan 15355, Korea. Electronic address: omfs1109@korea.ac.kr.
8. Department of Efficacy Research, Institute of Jinan Red Ginseng, Jinan 55442, Korea. Electronic address: yongsuk@jbnu.ac.kr.
- Publication Type:Journal Article
- Keywords:
Colitis;
Fermentation;
Inflammation;
Probiotics;
Red ginseng
- MeSH:
Administration, Oral;
Animals;
Colitis;
chemically induced;
drug therapy;
immunology;
Colon;
drug effects;
immunology;
Dextran Sulfate;
adverse effects;
Disease Models, Animal;
Female;
Fermentation;
Humans;
Interleukin-6;
immunology;
Lactobacillus plantarum;
metabolism;
Mice;
Mice, Inbred BALB C;
Panax;
chemistry;
metabolism;
microbiology;
Plant Extracts;
administration & dosage;
chemistry;
metabolism;
Powders;
administration & dosage;
metabolism;
Probiotics;
metabolism;
Tumor Necrosis Factor-alpha;
immunology
- From:
Chinese Journal of Natural Medicines (English Ed.)
2017;15(3):192-201
- CountryChina
- Language:English
-
Abstract:
Red ginseng is a well-known alternative medicine with anti-inflammatory activity. It exerts pharmacological effects through the transformation of saponin into metabolites by intestinal microbiota. Given that intestinal microflora vary among individuals, the pharmacological effects of red ginseng likely vary among individuals. In order to produce homogeneously effective red ginseng, we prepared probiotic-fermented red ginseng and evaluated its activity using a dextran sulfate sodium (DSS)-induced colitis model in mice. Initial analysis of intestinal damage indicated that the administration of probiotic-fermented red ginseng significantly decreased the severity of colitis, compared with the control and the activity was higher than that induced by oral administration of ginseng powder or probiotics only. Subsequent analysis of the levels of serum IL-6 and TNF-α, inflammatory biomarkers that are increased at the initiation stage of colitis, were significantly decreased in probiotic-fermented red ginseng-treated groups in comparison to the control group. The levels of inflammatory cytokines and mRNAs for inflammatory factors in colorectal tissues were also significantly decreased in probiotic-fermented red ginseng-treated groups. Collectively, oral administration of probiotic-fermented red ginseng reduced the severity of colitis in a mouse model, suggesting that it can be used as a uniformly effective red ginseng product.