Flavonoids isolated from Sinopodophylli Fructus and their bioactivities against human breast cancer cells.
10.1016/S1875-5364(17)30039-0
- Author:
Qing-Hui WANG
1
;
Shuai GUO
1
;
Xue-Yan YANG
1
;
Yi-Fan ZHANG
1
;
Ming-Ying SHANG
2
;
Ying-Hui SHANG
3
;
Jun-Jun XIAO
3
;
Shao-Qing CAI
1
Author Information
1. Department of Natural Medicine, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China.
2. Department of Natural Medicine, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China. Electronic address: myshang@bjmu.edu.cn.
3. Department of Cell Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.
- Publication Type:Journal Article
- Keywords:
Breast-cancer cell lines;
Flavonoid glycosides;
Prenylated flavonoids;
Sinopodophylli Fructus
- MeSH:
Antineoplastic Agents, Phytogenic;
chemistry;
isolation & purification;
pharmacology;
Berberidaceae;
chemistry;
Breast Neoplasms;
drug therapy;
physiopathology;
Cell Line, Tumor;
Cell Proliferation;
drug effects;
Flavonoids;
chemistry;
isolation & purification;
pharmacology;
Fruit;
chemistry;
Humans;
Molecular Structure
- From:
Chinese Journal of Natural Medicines (English Ed.)
2017;15(3):225-233
- CountryChina
- Language:English
-
Abstract:
Four prenylated flavonoids compounds 1-4, named sinopodophyllines A-D, and a flavonoid glycoside (compound 13), sinopodophylliside A, together with 19 known compounds (compounds 5-12 and 14-24) were isolated from the fruits of Sinopodophyllum hexandrum. The structures of new compounds were elucidated by extensive spectroscopic analysis, including HRESIMS, 1D and 2D NMR. Compounds 1-6, 9-11, and 14-17 were tested for their cytotoxicity against human breast-cancer T47D, MCF-7 and MDA-MB-231 cells in vitro, and compounds 2, 5, 6, 10 and 11 showed significant cytotoxicity (IC values < 10 μmol·L) against T47D cells.
