Megastigmane glucosides isolated from Dichrocephala benthamii.
10.1016/S1875-5364(17)30046-8
- Author:
Bo SONG
1
;
Jin-Guang SI
2
,
3
;
Meng YU
1
;
Xiao-Hui TIAN
1
;
Gang DING
4
;
Zhong-Mei ZOU
5
Author Information
1. Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.
2. Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China
3. Henan University of Traditional Chinese Medicine, Zhengzhou 450016, China.
4. Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China. Electronic address: dgfyhchina@163.com.
5. Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China. Electronic address: zmzou@implad.ac.cn.
- Publication Type:Journal Article
- Keywords:
Asteraceae;
Cytotoxicity;
Dichrocephala benthamii;
Megastigmane glucoside
- MeSH:
Antineoplastic Agents, Phytogenic;
chemistry;
isolation & purification;
pharmacology;
Asteraceae;
chemistry;
China;
Cyclohexanones;
chemistry;
isolation & purification;
pharmacology;
Drug Screening Assays, Antitumor;
Drugs, Chinese Herbal;
chemistry;
isolation & purification;
Glucosides;
chemistry;
isolation & purification;
pharmacology;
Hep G2 Cells;
Humans;
Molecular Structure;
Norisoprenoids;
chemistry;
isolation & purification;
pharmacology;
Plants, Medicinal
- From:
Chinese Journal of Natural Medicines (English Ed.)
2017;15(4):288-291
- CountryChina
- Language:English
-
Abstract:
The present study was designed to investigate the chemical constituents of the whole herb of Dichrocephala benthamii. A new megastigmane glucoside (compound 1), together with its four known analogues (compounds 2-5), was obtained. Their structures were elucidated on the basis of spectroscopic analyses (UV, IR, MS, and 1D and 2D NMR). The absolute configuration of compound 1 was assigned on the basis of CD method and chemical evidence. In addition, their cytotoxicity against human hepatoma cells (HepG-2) was evaluated by the MTT method. Compound 5 showed weak activity against HepG-2, while the other compounds did not show remarkable inhibitory effects.
