Two new diterpenoid lactones isolated from Andrographis paniculata.
10.1016/S1875-5364(17)30068-7
- Author:
Gui-Yang WANG
1
,
2
;
Ting WEN
1
,
2
;
Fei-Fei LIU
1
,
2
;
Hai-Yan TIAN
3
;
Chun-Lin FAN
1
,
2
;
Xiao-Jun HUANG
1
,
2
;
Wen-Cai YE
1
,
4
;
Ying WANG
1
,
5
Author Information
1. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China
2. JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research, College of Pharmacy, Jinan University, Guangzhou 510632, China.
3. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
4. JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research, College of Pharmacy, Jinan University, Guangzhou 510632, China. Electronic address: chywc@aliyun.com.
5. JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research, College of Pharmacy, Jinan University, Guangzhou 510632, China. Electronic address: wangying_cpu@163.com.
- Publication Type:Journal Article
- Keywords:
Acanthaceae;
Andrographis paniculata;
Diterpenoid lactones
- MeSH:
Andrographis;
chemistry;
Diterpenes;
chemistry;
isolation & purification;
Lactones;
chemistry;
isolation & purification
- From:
Chinese Journal of Natural Medicines (English Ed.)
2017;15(6):458-462
- CountryChina
- Language:English
-
Abstract:
In the present study, two new diterpenoid lactones, 3-deoxy-andrographoside (1) and 14-deoxy-15-methoxy-andrographolide (2), were isolated from the aerial parts of Andrographis paniculata. Their structures were elucidated by combination of NMR, MS, and chemical methods. The configurations of 1 and 2 were established based on the analysis of ROESY data and single crystal X-ray diffraction experiment.
