Triterpenoid saponins from the roots of Cyathula officinalis and their inhibitory effects on nitric oxide production.
10.1016/S1875-5364(17)30069-9
- Author:
Yun-Tao JIANG
1
,
2
;
Wen-Jing YAN
1
,
2
;
Chu-Lu QI
1
,
2
;
Ji-Qin HOU
1
,
2
;
Yan-Ying ZHONG
1
,
2
;
Hui-Jun LI
3
;
Hao WANG
1
,
4
;
Ping LI
3
Author Information
1. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China
2. Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
3. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
4. Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China. Electronic address: wanghao@cpu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Amaranthaceae;
Cyathula officinalis;
Nitric oxide inhibition;
Triterpenoid saponins
- MeSH:
Amaranthaceae;
chemistry;
Animals;
Anti-Inflammatory Agents;
isolation & purification;
Cells, Cultured;
Magnetic Resonance Spectroscopy;
Mice;
Nitric Oxide;
antagonists & inhibitors;
biosynthesis;
Plant Roots;
chemistry;
Saponins;
chemistry;
isolation & purification;
pharmacology;
Triterpenes;
chemistry;
isolation & purification;
pharmacology
- From:
Chinese Journal of Natural Medicines (English Ed.)
2017;15(6):463-466
- CountryChina
- Language:English
-
Abstract:
The present study was designed to investigate the chemical constituents of the roots of Cyathula officinalis. Compounds were isolated by silica gel, Sephadex LH-20, ODS column chromatography, and preparative HPLC. Their structures were determined on the basis of 1D and 2D NMR techniques, mass spectrometry, and chemical methods. One new oleanane-type triterpenoid saponin, 28-O-[α-L-rhamnopyranosyl-(1→3)-β-D-glucuronopyranosyl-(1→3)-β-D-glucopyranosyl] hederagenin (1), was isolated from the roots of Cyathula officinalis. The anti-inflammatory activities of the isolates were evaluated for their inhibitory effects against LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages cells. Compounds 2, 4, and 6 exhibited moderate anti-inflammatory activities.
