Antibacterial steroidal alkaloids from Holarrhena antidysenteriaca.
10.1016/S1875-5364(17)30080-8
- Author:
Li-Na ZHOU
1
;
Xiao-Lei GE
2
;
Ting-Ting DONG
2
;
Hui-Yuan GAO
2
;
Bo-Hang SUN
3
,
4
Author Information
1. School of Life Science and Biopharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang 110016, China.
2. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
3. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
4. Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: sunbohang1978@163.com.
- Publication Type:Journal Article
- Keywords:
Antibacterial;
Holarrhena antidysenteriaca;
MRSA;
MSSA;
Steroidal alkaloid;
Synergistic effect
- MeSH:
Alkaloids;
isolation & purification;
pharmacology;
Anti-Bacterial Agents;
chemistry;
isolation & purification;
pharmacology;
Holarrhena;
chemistry;
Methicillin-Resistant Staphylococcus aureus;
drug effects;
Microbial Sensitivity Tests;
Plant Extracts;
chemistry;
isolation & purification;
pharmacology;
Staphylococcus aureus;
drug effects
- From:
Chinese Journal of Natural Medicines (English Ed.)
2017;15(7):540-545
- CountryChina
- Language:English
-
Abstract:
Two new steroidal alkaloids, isoconkuressine and N-formylconessimine, together with 6 known steroidal alkaloids including conkuressine, conessine, isoconessimine, conimine, conarrhimine, and funtudienine, were isolated from the seeds of Holarrhena antidysenteriaca Wall.ex A.DC. Their intrinsic antibacterial activities and synergistic effects with penicillin and vancomycin were analyzed in methicillin sensitive staphylococcus aureus (MSSA) and methicillin resistant staphylococcus aureus (MRSA). Two of the steroidal alkaloids including one new compound (N-formylconessimine) showed potential antibacterial activity and possessed synergistic effects with penicillin and vancomycin, respectively.
