Tagetones A and B, new cytotoxic monocyclic diterpenoids from flowers of Tagetes minuta.
10.1016/S1875-5364(17)30081-X
- Author:
Sabrin Ragab Mohamed IBRAHIM
1
;
Gamal Abd Allah MOHAMED
2
Author Information
1. Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah 30078, Saudi Arabia. Electronic address: sabrinshaur@gmail.com.
2. Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
- Publication Type:Journal Article
- Keywords:
Asteraceae;
Cytotoxic;
Monocyclic diterpenoids;
Tagetes minuta;
Tagetones
- MeSH:
Cell Line, Tumor;
Cell Survival;
drug effects;
Diterpenes;
chemistry;
isolation & purification;
pharmacology;
Flowers;
chemistry;
Humans;
Plant Extracts;
chemistry;
isolation & purification;
pharmacology;
Tagetes;
chemistry
- From:
Chinese Journal of Natural Medicines (English Ed.)
2017;15(7):546-549
- CountryChina
- Language:English
-
Abstract:
Tagetones A (1) and B (2), two new monocyclic diterpenoids were isolated from the n-hexane fraction of fresh flowers of Tagetes minuta L. (Asteraceae). Their structures were established by multiple spectroscopic methods (IR, HR-ESI-MS, and 1D-, and 2D-NMR), in addition to comparison with literature data. Compound 1 showed cytotoxic activity towards MCF7 and A549 cancer cells with IC values being 4.68 and 4.24 µmol·L, respectively, compared to doxorubicin (IC 0.13 and 1.12 µmol·L, respectively). Compound 2 also exhibited significant activity against HCT116 cancer cells (IC, 6.30 µmol·L).
