Anti-colorectal cancer effects of tripolinolate A from Tripolium vulgare.
10.1016/S1875-5364(17)30085-7
- Author:
Lu CHEN
1
;
Wen-Ling WANG
1
;
Teng-Fei SONG
1
;
Xin XIE
2
;
Xue-Wei YE
1
;
Ying LIANG
1
;
Hao-Cai HUANG
1
;
Shi-Lun YAN
1
;
Xiao-Yuan LIAN
3
;
Zhi-Zhen ZHANG
4
Author Information
1. Ocean College, Zhoushan Campus, Zhejiang University, Zhoushan 316021, China.
2. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
3. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: xylian@zju.edu.cn.
4. Ocean College, Zhoushan Campus, Zhejiang University, Zhoushan 316021, China. Electronic address: zzhang88@zju.edu.cn.
- Publication Type:Journal Article
- Keywords:
Anti-colorectal tumor effects;
Apoptosis;
Cell cycle;
Colorectal cancer cells;
Tripolinolate A
- MeSH:
Animals;
Antineoplastic Agents, Phytogenic;
administration & dosage;
chemistry;
Apoptosis;
drug effects;
Asteraceae;
chemistry;
Cell Line, Tumor;
Cell Proliferation;
drug effects;
Colorectal Neoplasms;
drug therapy;
physiopathology;
Drugs, Chinese Herbal;
administration & dosage;
chemistry;
Esters;
administration & dosage;
chemistry;
G2 Phase;
drug effects;
Humans;
Male;
Mice;
Mice, Inbred BALB C;
Phenols;
administration & dosage;
chemistry
- From:
Chinese Journal of Natural Medicines (English Ed.)
2017;15(8):576-583
- CountryChina
- Language:English
-
Abstract:
Tripolinolate A (TLA) is recently identified as a new compound from a halophyte plant Tripolium vulgare and has been shown to have significant in vitro activity against the proliferation of colorectal cancer and glioma cells. This study was designed to further investigate the effects of TLA on the proliferation of human normal cells, and the apoptosis and cell cycle in colorectal cancer cells, and the growth of tumors in the colorectal cancer-bearing animals. The data obtained from this study demonstrated that: 1) TLA had much less cytotoxicity in the human normal cells than the colorectal cancer cells; 2) TLA remarkably induced apoptosis in the human colorectal cancer cells and blocked cell cycle at G/M phase, and 3) TLA had significant anti-colorectal cancer activity in the tumor-bearing animals.
