Two new phragmalin-type limonoids orthoesters from Entandrophragma candollei.
10.1016/S1875-5364(17)30097-3
- Author:
Olga QUASIE
1
,
2
;
Hui LI
3
;
Jun LUO
3
;
Ling-Yi KONG
4
Author Information
1. State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China
2. Centre for Plant Medicine Research, P.O. Box 73, Mampong-Akwapim, Ghana.
3. State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
4. State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China. Electronic address: cpu_lykong@126.com.
- Publication Type:Journal Article
- Keywords:
Entandrophragma candollei;
Inhibition;
Limonoids;
NO;
Phragmalin
- MeSH:
Animals;
Drugs, Chinese Herbal;
chemistry;
isolation & purification;
pharmacology;
Limonins;
chemistry;
isolation & purification;
pharmacology;
Macrophages;
drug effects;
metabolism;
Meliaceae;
chemistry;
Mice;
Molecular Structure;
Nitric Oxide;
metabolism;
Plant Bark;
chemistry;
RAW 264.7 Cells
- From:
Chinese Journal of Natural Medicines (English Ed.)
2017;15(9):680-683
- CountryChina
- Language:English
-
Abstract:
Two new phragmalin-type limonoids orthoesters, encandollens A and B (1 and 2), were isolated from the stem barks of Entandrophragma candollei collected in Ghana. The structures of these compounds were elucidated on the basis of HR-ESI-MS, H and C NMR, HSQC, HMBC, and ROESY data. Compound 1 was a rare C-15 enolic acyl phragmalin-type limonoid orthoester. Compounds 1 and 2 exhibited weak inhibitory effects on NO production in lipopolysaccharide (LPS)-induced RAW 264.7 cells.
