Clavuridins A and B, two new trinor-guaiane sesquiterpenes isolated from the Xisha soft coral Clavularia viridis.
10.1016/S1875-5364(18)30019-0
- Author:
Yuan GAO
1
;
Wei XIAO
2
;
Hong-Chun LIU
3
;
Jian-Rong WANG
3
;
Li-Gong YAO
3
;
Ping-Kai OUYANG
1
;
De-Cai WANG
4
;
Yue-Wei GUO
5
Author Information
1. College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China.
2. Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222002, China.
3. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
4. College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China. Electronic address: dcwang@njtech.edu.cn.
5. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. Electronic address: ywguo@simm.ac.cn.
- Publication Type:Journal Article
- Keywords:
Clavularia viridis;
Cytotoxic activity;
Soft coral;
Trinor-guaiane sesquiterpene
- MeSH:
Animals;
Anthozoa;
chemistry;
Biological Products;
chemistry;
pharmacology;
Magnetic Resonance Spectroscopy;
Molecular Structure;
Sesquiterpenes, Guaiane;
chemistry;
isolation & purification;
pharmacology
- From:
Chinese Journal of Natural Medicines (English Ed.)
2017;15(11):855-859
- CountryChina
- Language:English
-
Abstract:
In the present study, two new trinor-guaiane sesquiterpenes, named clavuridins B (1), and A (2), along with three known sesquiterpenes (3-5), were isolated from the Xisha soft coral Clavularia viridis. Their structures and absolute configurations were determined on the basis of spectroscopic analysis, X-ray diffraction analysis with Cu Kα radiation and by comparison with related model compounds. Compounds 1 and 3-5 were evaluated for their cytotoxic activity.
