New diterpenoids isolated from Leonurus japonicus and their acetylcholinesterase inhibitory activity.
10.1016/S1875-5364(18)30020-7
- Author:
Han-Kui WU
1
;
Ting SUN
2
;
Feng ZHAO
2
;
Li-Ping ZHANG
2
;
Gang LI
2
;
Jie ZHANG
3
Author Information
1. College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, China. Electronic address: hkwu@aynu.edu.cn.
2. College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, China.
3. Key Laboratory of Natural Medicine and Immuno-Engineering, Henan University, Kaifeng 475004, China. Electronic address: jiezhang@henu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Acetylcholinesterase;
Labdane diterpenoid;
Leojaponicone;
Leonurus japonicus
- MeSH:
Acetylcholinesterase;
metabolism;
Cholinesterase Inhibitors;
chemistry;
isolation & purification;
pharmacology;
Diterpenes;
chemistry;
isolation & purification;
pharmacology;
Glycoside Hydrolase Inhibitors;
chemistry;
isolation & purification;
pharmacology;
Leonurus;
chemistry;
Magnetic Resonance Spectroscopy;
Molecular Structure;
Plant Extracts;
chemistry;
pharmacology
- From:
Chinese Journal of Natural Medicines (English Ed.)
2017;15(11):860-864
- CountryChina
- Language:English
-
Abstract:
Three new labdane diterpenoids, leojaponicone A (1), isoleojaponicone A (2) and methylisoleojaponicone A (3), were isolated from the herb of Leonurus japonicus. The chemical structures of these secondary metabolites were elucidated on the basis of 1D and 2D NMR, including HMQC, and HMBC spectroscopic techniques. All the new compounds were tested in vitro for their acetylcholinesterase and α-glucosidase inhibitory activity. Compounds 1-3 exhibited low inhibitory effects on α-glucosidase with respect to acarbose and exhibited high inhibitory effects on acetylcholinesterase with respect to huperzine A.
