Anticancer carbazole alkaloids and coumarins from Clausena plants: A review.
10.1016/S1875-5364(18)30003-7
- Author:
Li HUANG
1
;
Zhe-Ling FENG
1
;
Yi-Tao WANG
1
;
Li-Gen LIN
2
Author Information
1. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China.
2. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China. Electronic address: ligenl@umac.mo.
- Publication Type:Journal Article
- Keywords:
Anticancer;
Carbazole alkaloids;
Clausena;
Coumarins
- MeSH:
Alkaloids;
chemistry;
pharmacology;
therapeutic use;
Antineoplastic Agents;
chemistry;
pharmacology;
therapeutic use;
Apoptosis;
drug effects;
Carbazoles;
chemistry;
pharmacology;
therapeutic use;
Cell Cycle Checkpoints;
drug effects;
Clausena;
chemistry;
Coumarins;
chemistry;
pharmacology;
therapeutic use;
Drugs, Chinese Herbal;
chemistry;
pharmacology;
therapeutic use;
Humans;
Plants, Medicinal;
chemistry
- From:
Chinese Journal of Natural Medicines (English Ed.)
2017;15(12):881-888
- CountryChina
- Language:English
-
Abstract:
Pharmaceutical research has focused on the discovery and development of anticancer drugs. Clinical application of chemotherapy drugs is limited due to their severe side effects. In this regard, new naturally occurring anticancer drugs have gained increasing attention because of their potential effectiveness and safety. Fruits and vegetables are promising sources of anticancer remedy. Clausena (family Rutaceae) is a genus of flowering plants and includes several kinds of edible fruits and vegetables. Phytochemical and pharmacological studies show that carbazole alkaloids and coumarins from Clausena plants exhibit anticancer activity. This review summarizes research progresses made in the anticancer properties of plants belonging to Clausena; in particular, compounds with direct cytotoxicity, cell cycle arrest, apoptosis induction, and immune potentiation effects are discussed. This review reveals the potential use of plants from Clausena in preventing and treating cancer and provides a basis for development of relevant therapeutic agents.
