Effects of Gardenia jasminoides extracts on cognition and innate immune response in an adult Drosophila model of Alzheimer's disease.
10.1016/S1875-5364(18)30005-0
- Author:
Wei-Wei MA
1
,
2
;
Ye TAO
3
;
Yan-Ying WANG
3
;
I-Feng PENG
4
Author Information
1. School of Life Science, Tsinghua University, Beijing 100084, China
2. Suzhou Joekai Biotech LLC, Kunshan City, Jiangsu, 215300, China.
3. Suzhou Joekai Biotech LLC, Kunshan City, Jiangsu, 215300, China.
4. Suzhou Joekai Biotech LLC, Kunshan City, Jiangsu, 215300, China. Electronic address: ifengpeng@joekaibiotech.com.
- Publication Type:Journal Article
- Keywords:
Crocin;
Gardenia jasminoides;
Gardenoside;
Geniposide;
Inflammation;
Memory;
Neurodegenerative diseases
- MeSH:
Alzheimer Disease;
drug therapy;
Animals;
Antimicrobial Cationic Peptides;
genetics;
Brain;
drug effects;
immunology;
Cognition;
drug effects;
Disease Models, Animal;
Drosophila;
Drosophila Proteins;
genetics;
Gardenia;
chemistry;
Gene Expression Regulation;
drug effects;
Immunity, Innate;
drug effects;
Iridoids;
chemistry;
isolation & purification;
pharmacology;
Plant Extracts;
chemistry;
isolation & purification;
pharmacology;
Polymerase Chain Reaction
- From:
Chinese Journal of Natural Medicines (English Ed.)
2017;15(12):899-904
- CountryChina
- Language:English
-
Abstract:
Herbal extracts have been extensively used worldwide for their application on memory improvement, especially among aged and memory-deficit populations. In the present study, the memory loss induced by human Abeta protein over-expression in fruitfly Alzheimer's disease (AD) model was rescued by multiple extracts from Gardenia jasminoides. Three extracts that rich with gardenia yellow, geniposide, and gardenoside components showed distinct rescue effect on memory loss. Further investigation on adding gardenoside into a formula of Ganoderma lucidum, Panax notoginseng and Panax ginseng (GPP) also support its therapeutic effects on memory improvement. Interestingly, the application of GPP and gardenoside did not alter the accumulation of Abeta proteins but suppressed the expression of immune-related genes in the brain. These results revealed the importance and relevancy of anti-inflammation process and the underlying mechanisms on rescuing memory deficits, suggesting the potential therapeutic use of the improved GPP formulation in improving cognition in defined population in the future.
