Atractylodes lancea rhizome water extract reduces triptolide-induced toxicity and enhances anti-inflammatory effects.
10.1016/S1875-5364(18)30006-2
- Author:
Yuan WEI
1
;
Dan-Juan SUI
2
;
Hai-Miao XU
2
;
Zhen OUYANG
2
;
Na WU
2
;
Du-Jun WANG
2
;
Xiao-Yan ZHANG
2
;
Da-Wei QIAN
3
Author Information
1. School of Pharmacy, Jiangsu University, Zhenjiang 212013, China. Electronic address: ywei@ujs.edu.cn.
2. School of Pharmacy, Jiangsu University, Zhenjiang 212013, China.
3. Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing 210023, China.
- Publication Type:Journal Article
- Keywords:
Anti-inflammation effects;
Atractylodes lancea;
CYP3A;
Licorice;
Triptolide
- MeSH:
Animals;
Anti-Inflammatory Agents;
isolation & purification;
pharmacology;
Atractylodes;
chemistry;
Cytochrome P-450 Enzyme System;
genetics;
Diterpenes;
toxicity;
Edema;
chemically induced;
pathology;
Enzyme Induction;
drug effects;
Epoxy Compounds;
toxicity;
Gene Expression Regulation;
drug effects;
Herb-Drug Interactions;
Liver;
drug effects;
pathology;
Male;
Mice;
Mice, Inbred C57BL;
Phenanthrenes;
toxicity;
Plant Extracts;
isolation & purification;
pharmacology;
Plants, Medicinal;
chemistry;
Rhizome;
chemistry;
Water;
chemistry
- From:
Chinese Journal of Natural Medicines (English Ed.)
2017;15(12):905-911
- CountryChina
- Language:English
-
Abstract:
The present study was designed to explore the influence of water extracts of Atractylodes lancea rhizomes on the toxicity and anti-inflammatory effects of triptolide (TP). A water extract was prepared from A. lancea rhizomes and co-administered with TP in C57BL/6 mice. The toxicity was assayed by determining serum biochemical parameters and visceral indexes and by liver histopathological analysis. The hepatic CYP3A expression levels were detected using Western blotting and RT-PCR methods. The data showed that the water extract of A. lancea rhizomes reduced triptolide-induced toxicity, probably by inducing the hepatic expression of CYP3A. The anti-inflammatory effects of TP were evaluated in mice using a xylene-induced ear edema test. By comparing ear edema inhibition rates, we found that the water extract could also increase the anti-inflammatory effects of TP. In conclusion, our results suggested that the water extract of A. lancea rhizomes, used in combination with TP, has a potential in reducing TP-induced toxicity and enhancing its anti-inflammatory effects.
