Three new anthraquinone derivatives isolated from Symplocos racemosa and their antibiofilm activity.
10.1016/S1875-5364(18)30011-6
- Author:
Umar FAROOQ
1
;
Sara KHAN
2
;
Sadia NAZ
2
;
Ajmal KHAN
3
;
Afsar KHAN
4
;
Ayaz AHMED
5
;
Abdur RAUF
6
;
Syed Majid BUKHARI
2
;
Shujaat Ali KHAN
7
;
Arfa KAMIL
8
;
Nadia RIAZ
9
;
Abdur Rahman KHAN
2
Author Information
1. Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad-22060, Pakistan. Electronic address: umarf@ciit.net.pk.
2. Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad-22060, Pakistan.
3. Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad-22060, Pakistan. Electronic address: ajmalkhan@ciit.net.pk.
4. Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad-22060, Pakistan. Electronic address: afsarkhan@ciit.net.pk.
5. Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi-75270, Pakistan.
6. Department of Geology, University of Swabi Anbar-23430, KPK, Pakistan.
7. Institute of Chemical Sciences, University of Peshawar, Peshawar 25120, Pakistan.
8. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Federal Urdu University of Arts, Science and Technology, Karachi, Karachi 75300, Pakistan.
9. Department of Environmental Sciences, COMSATS Institute of Information Technology, Abbottabad-22060, Pakistan.
- Publication Type:Journal Article
- Keywords:
Antibiofilm activity;
Substituted anthraquinone;
Symplocos racemosa
- MeSH:
Anthraquinones;
chemistry;
isolation & purification;
pharmacology;
Anti-Bacterial Agents;
chemistry;
isolation & purification;
pharmacology;
Biofilms;
drug effects;
growth & development;
Ericales;
chemistry;
Magnetic Resonance Spectroscopy;
Mass Spectrometry;
Methicillin-Resistant Staphylococcus aureus;
drug effects;
physiology;
Microbial Sensitivity Tests;
Proteus mirabilis;
drug effects;
physiology;
Spectrophotometry, Infrared;
Streptococcus mutans;
drug effects;
physiology
- From:
Chinese Journal of Natural Medicines (English Ed.)
2017;15(12):944-949
- CountryChina
- Language:English
-
Abstract:
Three new alkyl substituted anthraquinone derivatives, trivially named as symploquinones A-C (Compounds 1-3) were isolated from Symplocos racemosa. The structures of these compounds were determined on the basis of extensive spectroscopic analyses (UV, IR, Mass, H- and C-NMR, and two-dimensional (2D) NMR techniques). The resulting data were also compared with the reported literature. These compounds were then subjected to antibacterial or antibiofilm testing. Compounds 1 and 3 exhibited good antibacterial activity in the concentration range of 160-83 μg·mL against Streptococcus mutans, methicillin resistant Staphylococcus aureus and Proteus mirabilis. Both compounds were further screened for anti-biofilm activity, which revealed promising activities at sub-MIC concentrations. None of the compounds were found to be active against Klebsiella pneumoniae.
