Cycloartane triterpenoid and its glucoside isolated from Cassia occidentalis.
10.1016/S1875-5364(18)30012-8
- Author:
Shi-Fei LI
1
;
Shun-Lin LI
2
Author Information
1. Institute of Molecular Science, Shanxi University, Taiyuan 030006, China. Electronic address: lisf@sxu.edu.cn.
2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic address: lisl@mail.kib.ac.cn.
- Publication Type:Journal Article
- Keywords:
Cassia occidentalis;
Cycloartane triterpenoid;
Cycloccidentalic acid C;
Cycloccidentaliside VI
- MeSH:
Anti-HIV Agents;
isolation & purification;
pharmacology;
Cell Line, Tumor;
Cell Survival;
drug effects;
Glucosides;
chemistry;
pharmacology;
toxicity;
Humans;
Inhibitory Concentration 50;
Magnetic Resonance Spectroscopy;
Molecular Structure;
Plant Extracts;
chemistry;
isolation & purification;
pharmacology;
toxicity;
Senna Plant;
chemistry;
Triterpenes;
chemistry;
isolation & purification;
pharmacology;
toxicity
- From:
Chinese Journal of Natural Medicines (English Ed.)
2017;15(12):950-954
- CountryChina
- Language:English
-
Abstract:
In the present study, one new cycloartane triterpenoid, named cycloccidentalic acid C (1) and its glucoside, cycloccidentaliside VI (2) were isolated from the whole plant of Cassia occidentalis. Their structures were elucidated by a combinational analyses of 1D and 2D NMR data and HRMS. Compound 2 showed modest anti-HIV-1 activity with EC value of 1.44 μmol·L and TI (Therapeutic Index) value of 15.59.
