New strategies for CAR-T cell in the treatment of solid tumors
10.3872/j.issn.1007-385x.2018.09.002
- VernacularTitle:CAR-T细胞治疗实体肿瘤的新策略
- Author:
WU Shaoxian
1
,
2
;
XIA Jianchuan
3
;
JIANG Jingting
1
,
2
Author Information
1. Department of Tumor Biological Treatment &
2. Institute of Cell Therapy, The Third Affiliated Hospital of Soochow University
3. Biotherapy Center, Cancer Hospital of Sun Yat-sen University
- Publication Type:Journal Article
- Keywords:
chimeric antigen receptor modified T ( CAR-T) cell;
solid tumor;
immunosuppressive microenvironment
- From:
Chinese Journal of Cancer Biotherapy
2018;25(9):854-858
- CountryChina
- Language:Chinese
-
Abstract:
Chimeric antigen receptor modified T (CAR-T) cell, a novel adoptive immunotherapy strategy, has been used successfully against hematological tumors. However, in solid tumors, due to multiple immunosuppressive cells, immunosuppressive molecules, and extracellular matrix play a suppressive role in the cytotoxic effects of migrating CAR-T cells and severely inhibit the antitumor efficacy of CAR-T cells in the tumor microenvironment of solid tumors. Simultaneously, tumor heterogeneity, lacking proper tumor antigens, poor homing ability at solid tumor sites, along with off-target effect, resulting in poor therapeutic effect of CAR-T cells in solid tumors. Compared with hematological tumors, solid tumors have complex biological characteristics, and thus targeted strategies are demanded to ensure long-term efficacy of CAR-T cells against tumors. This review makes a summary of the development of CAR-T cells, the confusion in solid tumors and the progress of treatment strategies.
- Full text:20180902.pdf
