Advances on hypoglycemic activity and mechanism of triterpenoids

VernacularTitle:三萜类化合物降血糖活性及其作用机制研究进展
Author: Kuiniu ZHU ^{1
,

2} ; Zhengfeng WU ; Cuihua JIANG ; Lanjie CAO ; Jian ZHANG ; YIN YIN
Author Information

1. 中国药科大学天然药物化学教研室&
2. 天然药物活性组分与药效国家重点实验室；江苏省中医药研究院转化医学实验室
Publication Type:Journal Article
Keywords: triterpenoids; hypoglycemic effects; mechanisms; advances
From: Journal of China Pharmaceutical University 2015;46(6):764-770
CountryChina
Language:Chinese
Abstract: The research of triterpenoids on hypoglycemic and anti-diabetic activities have made great progress. Findings indicated that triterpenoids could reduce blood glucose via different mechanisms, including increasing insulin secretion, enhancing insulin sensitivity, promoting glucose uptake by activation of AMP-activated protein kinase(AMPK), decreasing glycogenolysis and gluconeogenesis, and inhibiting protein tyrosine phosphates 1B(PTP1B), α-glycosidase, aldose reductase(AR)and dipeptidyl peptidase-4(DPP-4). This article reviews the hypoglycemic effects and mechanisms of triterpenoids, providing the reference for further research and development of triterpenoids.