Preparation and in vitro properties of paclitaxel-loaded mesoporous silica nanoparticle

VernacularTitle:荷载紫杉醇介孔二氧化硅纳米粒的制备及体外性能
Author: Xue ZHANG ¹ ; Zhigui SU ; Lingjing XUE ; Can ZHANG
Author Information

1. 中国药科大学新药研究中心，江苏省代谢性疾病药物研究重点实验室
Publication Type:Journal Article
Keywords: mesoporous silica nanoparticles; paclitaxel; in vitro drug release; anti-tumor activity
From: Journal of China Pharmaceutical University 2015;46(6):653-658
CountryChina
Language:Chinese
Abstract: Mesoporous silica nanoparticle as drug carrier has become the new research focus in the field of nano-drug delivery system in recent years. In this study, paclitaxel-loaded msesoporous silica nanoparticle(PTX@MSN)was manufactured by the solvent adsorption. In vitro studies revealed that PTX@MSN was well dispersed in aqueous medium with particle size of 250 nm, the potential of -(8. 01±1. 81)mV and drug loading efficiency of(23. 76±1. 14)%. PTX@MSN showed the sustained-release characteristics with the cumulative PTX of release(23. 62±2. 15)% at 24 h. In additions, the cytotoxicity investigation indicated that blank MSNs were biocompatible while PTX@MSN group showed improved in vitro anti-tumor activity against HepG2 cell when compared with Taxol group. In conclusion, MSN is a promising platform to build drug delivery systems for tumor therapy.