Antitumor effect of peptide mPEG-SC20k-HM-3 and oxaliplatin combination against human hepatocellular carcinoma SMMC-7721 in nude mice
10.11665/j.issn.1000-5048.20150415
- VernacularTitle:多肽mPEG-SC20k-HM-3联合奥沙利铂对人肝癌细胞SMMC-7721裸鼠移植瘤的抑制作用
- Author:
Junjin HE
1
;
Jiayi WANG
;
Jingchao HAO
;
Haoran CHENG
;
Hanmei XU
Author Information
1. 中国药科大学多肽药物创制工程研究中心
- Publication Type:Journal Article
- Keywords:
peptide;
mPEG-SC20k-HM-3;
hepatocellular carcinoma;
anti-angiogenesis;
oxaliplatin;
drug combination;
transplanted tumor nude mice model
- From:
Journal of China Pharmaceutical University
2015;46(4):476-480
- CountryChina
- Language:Chinese
-
Abstract:
mPEG-SC20k-HM-3 is a novel anti-angiogenesis peptide with integrin affinity. To investigate the anti-tumor activities of mPEG-SC20k-HM-3 and oxaliplatin(OXA)combination, a transplanted tumor model of human hepatocellular carcinoma SMMC-7721 in nude mice was established. Jin′s formula to evaluate the combination effect was used. Data suggested that the anti-tumor activities of combined groups were better than those of single drug(P< 0. 05). Inhibition rate of group 8(OXA 7. 5 mg/kg and mPEG-SC20k-HM-3 73. 4 mg/kg)was 84. 6%, which showed remarkable superiority to group 3(OXA 7. 5 mg/kg)and group 4(mPEG-SC20k-HM-3 73. 4 mg/kg). The Q of group 8 was 1. 164(> 1. 15). This combination had synergistic effect. Combination of mPEG-SC20k-HM-3 and oxaliplatin is a method of inhibiting hepatocellular carcinoma.
