Recent research progress in small molecule AMPK direct activators

VernacularTitle:小分子AMPK直接激动剂的最新研究进展
Author: Qiangqiang WEI ¹ ; Wenhu DUAN ; Jinpei ZHOU ; Huibin ZHANG
Author Information

1. 中国药科大学新药研究中心
Publication Type:Journal Article
Keywords: AMP-activated protein kinase; AMPK direct activators; structure-activity relationship; type 2 diabetes; new target; advances
From: Journal of China Pharmaceutical University 2015;46(4):406-415
CountryChina
Language:Chinese
Abstract: Type 2 diabetes, an epidemic disorder characterized by high blood glucose level associated with microvascular complications, is one of the main causes of human suffer across the globe, with no effective medicine up to now. AMP-activated protein kinase(AMPK), a highly conserved serine/threonine protein kinase, is a key sensor and regulator of intracellular and whole-body energy metabolism. Small molecule AMPK direct activators have been proven to lower blood-glucose, which is a promising candidate for the treatment of type 2 diabetes. The progress on the research of small molecule AMPK direct activators in recent years is summarized in this paper.