Roles of Moesin in tumor progression
10.11665/j.issn.1000-5048.20150319
- VernacularTitle:Moesin蛋白在肿瘤进展中的作用
- Author:
Jinghui ZHANG
1
;
Yajing WANG
;
Rong HU
Author Information
1. 中国药科大学生理学教研室
- Publication Type:Journal Article
- Keywords:
Moesin;
tumor progression;
target;
signal transduction;
cytoskeleton;
CD44/Moesin inhibitor
- From:
Journal of China Pharmaceutical University
2015;46(3):371-375
- CountryChina
- Language:Chinese
-
Abstract:
Moesin is a component of ERM(Ezrin/Radixin/Moesin)family proteins linking cell membrane proteins with cytoskeleton. It is involved in cell morphological change and the maintaining of cell cortex and is also involved in cell adhesion, migration and polarization by regulating the signal transduction pathways. Moesin plays a vital role in several aspects of tumor initiation and progression through its regulation on cytoskeleton and signal transduction pathways. This article reviews the close relation between Moesin and its phosphorylated form with the higher level of malignancy and poor prognosis through clinic data analysis. Furthermore, the role and mechanism of Moesin on tumor migration, EMT and tumor proliferation are presented. Drug research and development based on the target of Moesin are also concluded.
