Ophthalmic solution of thiolated chitosan-pirenoxine sodium-layered double hydroxides hybrid nanocomposites
10.11665/j.issn.1000-5048.20150211
- VernacularTitle:巯基化壳聚糖-吡诺克辛钠-层状双氢氧化物纳米复合物滴眼液的研究
- Author:
Jie ZHANG
1
;
Huibo CHI
;
Yanju CHENG
;
Feng CAO
Author Information
1. 中国药科大学药剂学教研室
- Publication Type:Journal Article
- Keywords:
layered double hydroxides;
pirenoxine sodium;
eye drops;
thiolated chitosan;
hybrid nanocomposites;
co-precipitation method;
in vitro release;
precorneal retention
- From:
Journal of China Pharmaceutical University
2015;46(2):201-208
- CountryChina
- Language:Chinese
-
Abstract:
Ophthalmic solution of organic-inorganic layered double hydroxides hybrid nanocomposites based on layered double hydroxides(LDH)intercalated with pirenoxine sodium(PRN)and chitosan-glutathione(CG)was prepared, characterized and evaluated using rabbit precorneal retention. Mg-Al-PRN-LDH, Zn-Al-PRN-LDH and CG-PRN-LDH were synthesized by co-precipitation. The nanocomposites were characterized by laser particle sizer, powder X-ray diffraction(X-RD), fourier transform infrared spectra(FTIR)and transmission electron micrographs(TEM). The release of PRN from Mg-Al-PRN-LDH, Zn-Al-PRN-LDH, and CG-PRN-LDH nanocomposites and API in artificial tear was compared. Based on in vivo precorneal retention studies, PRN-LDH and CG-PRN-LDH nanocomposite dispersions showed significantly higher AUC(3. 72-, 7. 59-folds)and MRT(2. 18-, 2. 60-folds)than that of the commercial eye drops group. Organic-inorganic layered double hydroxides hybrid nanocomposites CG-PRN-LDH dispersions could remarkably improve precorneal retention of PRN.
