Synthesis of(Z)-methyl-2-acetamidocinnamate
10.11665/j.issn.1000-5048.20150207
- VernacularTitle:(Z)-2-乙酰氨基肉桂酸甲酯的合成
- Author:
Haitao CHEN
1
;
Xianying DUAN
;
Wenxin WANG
;
Jingguo FU
;
Guanyu YANG
;
Ji LI
Author Information
1. 河南省科学院化学研究所有限公司；郑州大学化学与分子工程学院
- Publication Type:Journal Article
- Keywords:
(Z)-methyl-2-acetamidocinnamate;
synthesis;
dicyclohexylcarbodiimide;
4-dimethylaminopyridine;
(Z)-2-acetamidocinnamic acid
- From:
Journal of China Pharmaceutical University
2015;46(2):178-180
- CountryChina
- Language:Chinese
-
Abstract:
In the investigation of asymmetric catalytic hydrogenation reaction, (Z)-methyl-2-acetamidocinnamate is often used as a standard substrate to assess the chiral catalysts. However, its previous syntheses suffered from low yield, relying on column chromatography for isolation. Herein, (Z)-methyl-2-acetamidocinnamate was obtained with 68. 5% isolation yield via simple operations such as wash and extraction using dicyclohexylcarbodiimide(DCC)as dehydrant and 4-dimethylaminopyridine(DMAP)as catalyst in the last synthetic step.
