Design, synthesis and antiproliferative activity of scopoletin derivatives
10.11665/j.issn.1000-5048.20150205
- VernacularTitle:东莨菪素衍生物的设计、合成及抗增殖活性
- Author:
Jinglin HU
1
;
Linhu LI
;
Li CHEN
Author Information
1. 中国药科大学天然药物化学教研室
- Publication Type:Journal Article
- Keywords:
scopoletin;
derivative;
synthesis;
antiproliferative activity
- From:
Journal of China Pharmaceutical University
2015;46(2):169-173
- CountryChina
- Language:Chinese
-
Abstract:
To explore novel scopoletin derivatives with more potent antiproliferative activity, a series of compounds were designed and synthesized(10a-10i)by linking benzamide to scopoletin′s framework. Their structures were determined by ESI-MS, IR and 1H NMR. The antiproliferative activity of the synthetic derivatives against human cancer cells MCF-7, A549 and HCT-116 was evaluated by MTT assay. Preliminary experimental results showed that compound 10g was the most potent one, whose antiproliferative activity was stronger than that of the positive control scopoletin and sunitinib.
