Protective effects of Naomaili granules on cerebral ischemia-reperfusion in rats and its mechanism
10.11665/j.issn.1000-5048.20150115
- VernacularTitle:脑脉利颗粒对大鼠脑缺血再灌注损伤的保护作用及其机制
- Author:
Yi REN
1
;
Mei SU
;
Jing ZHENG
;
Yinlin QIN
;
Tao CHEN
;
Hui JI
Author Information
1. 中国药科大学药理学教研室
- Publication Type:Journal Article
- Keywords:
Naomaili granules;
cerebral ischemia-reperfusion;
middle cerebral artery occlusion reperfusion models;
free radical antioxidation
- From:
Journal of China Pharmaceutical University
2015;46(1):100-104
- CountryChina
- Language:Chinese
-
Abstract:
The objective of the study was to determine the potential effects of Naomaili granules on rats subjected to ischemia and reperfusion. With the exception of animals in sham group, all animals in treatment groups were subjected to ischemia and reperfusion by middle cerebral artery occlusion(MCAO)with thread technique. The ability of anti-cerebral ischemia, relieving cerebral edema and antioxidation was evaluated by the measurement of neurological deficit score, ratios of infarction area, brain water content, histopathological score and biochemical indexes related to oxidative stress in brain tissue. Significantly reduction of infarction area, histopathological score, contents of H2O2 and MDA were observed at 6 g/kg and 3 g/kg Naomaili granules compared to animals in the model group; the capacity of inhibition of superoxide anion radical(O-·2)and hydroxyl radial( ·OH)were also found to have increased. Additionally, Naomaili granules(6 g/kg)improved neurological function, reduced brain water content, and increased the level of GSH, GSH-Px and SOD compared with model group. The result suggested that Naomaili granules exhibited obvious protection against cerebral ischemia and reperfusion-induced injury due to its antioxidating effect.
