Synthesis and anti-tumor activity in vitro of N-hetercycle substituted benzofuran derivatives
10.11665/j.issn.1000-5048.20150106
- VernacularTitle:N-杂环取代苯并呋喃衍生物的合成及抗肿瘤活性
- Author:
Zewei MAO
1
;
Chunping WAN
;
Yuan JIANG
;
Wenlian GUO
;
Gaoxiong RAO
Author Information
1. 云南中医学院药学院
- Publication Type:Journal Article
- Keywords:
N-hetercycle;
benzofuran derivatives;
synthesis;
anti-tumor activity
- From:
Journal of China Pharmaceutical University
2015;46(1):58-61
- CountryChina
- Language:Chinese
-
Abstract:
To discover the novel compounds with biological activity, N-hetercycle substituted derivatives were synthesized based on the structure of benzofuran. A series of novel N-hetercycle substituted benzofuran derivatives(2a-2j)were synthesized by the reaction of 2-(4′-florobenzoyl)benzofuran with N-heterocyclic compounds. And the structures were characterized by 1H NMR, 13C NMR and HRMS. Their anti-tumor activities were studied in vitro against a panel of human tumor cell lines(HeLa, A549 and H1975)by the MTT assay. The results indicate that compounds 2a, 2f and 2j are the most potent within this series of compounds against human tumor cell lines, showing that they are promising lead compounds for further structural modifications and biological evaluation.
