Advances in recombinant polypeptide mimetics of PEG
10.11665/j.issn.1000-5048.20160603
- VernacularTitle:模拟PEG的聚多肽融合技术研究进展
- Author:
Rong CHEN
1
;
Jun YIN
;
Mei SHAO
;
Wenbing YAO
;
Xiangdong GAO
Author Information
1. 中国药科大学生命科学与技术学院
- Publication Type:Journal Article
- Keywords:
polypeptide fusion technology;
therapeutic proteins;
plasma half-life;
hydrodynamic volume;
glomerular filtration
- From:
Journal of China Pharmaceutical University
2016;47(6):648-653
- CountryChina
- Language:Chinese
-
Abstract:
Peptide and protein biologics possess high specificity and high biological activity, but their poor stability and short plasma half-life have limited clinical application. One established strategy to increase half-life of therapeutic proteins is chemical conjugation of the biologic with PEG. Nevertheless, PEGylation technology has some drawbacks, so recombinant polypeptide mimetics of PEG have gradually developed in recent years. Pharmaceutically active protein can be fused with specific amino acid sequences using recombinant DNA technology, and then increase hydrodynamic volume or produce charge effect, which retards kidney filtration and eventually prolongs the half-life. This article mainly reviews kinds of polypeptides and the research progress in half-life extension of therapeutic proteins.
