Effects of honokiol on TTX-S sodium current in mouse dorsal root ganglion neurons
10.11665/j.issn.1000-5048.20160518
- VernacularTitle:和厚朴酚对小鼠背根神经节河豚毒素敏感型钠电流的影响
- Author:
Yun HUANG
1
;
Ziyao KANG
;
Guangqin ZHANG
Author Information
1. 中国药科大学临床药学教研室
- Publication Type:Journal Article
- Keywords:
honokiol;
dorsal root ganglion;
tetrodotoxin-sensitive sodium currents;
whole-cell patch clamp;
analgetics
- From:
Journal of China Pharmaceutical University
2016;47(5):609-613
- CountryChina
- Language:Chinese
-
Abstract:
To elucidate possible mechanisms and targets of honokiol(Hnk)for hte treatment of pain, the effects of Hnk on tetrodoxin-senstive(TTX-S)sodium current(INa)were studied in acutely dissociated mouse dorsal root ganglion(DRG)neurons with whole-cell patch clamp technique. Hnk inhibited TTX-S INa currents in a concentration-dependent manner. At 30 μmol/L, Hnk obviously shifted the steady state activation of TTX-S INa toward more positive potentials by 10. 2 mV and prolonged the time course of recovery of sodium current, yet with no significant difference on recovery from inactivation of TTX-S sodium channel.
