Phenolic constituents of Galla Chinensis and their antiviral activities
10.11665/j.issn.1000-5048.20160510
- VernacularTitle:五倍子中酚性化学成分及其抗病毒活性
- Author:
Hanbing YANG
1
;
Wenqiang YANG
;
Min SONG
;
Jian ZHANG
;
Xiaoqi ZHANG
;
Wencai YE
Author Information
1. 暨南大学药学院中药及天然药物研究所；暨南大学广东省中药药效物质基础与创新药物研究重点实验室
- Publication Type:Journal Article
- Keywords:
Galla Chinensis;
chemical constituents;
isolation and identification;
hydrolysable tannins;
antiviral acticvity
- From:
Journal of China Pharmaceutical University
2016;47(5):566-569
- CountryChina
- Language:Chinese
-
Abstract:
Seven compounds in the 95% ethanol extract of Galla Chinensis were isolated by silica gel, ODS, Toyopearl HW-40(s)and RP-HPLC. Their structures were identified on the basis of spectral data and physicochemical properties as benzoic acid, 3, 4-dihydroxy-5-［(3, 4, 5-trihydroxybenzoyl)oxy］-, 5-ethoxycarbonyl-2, 3-dihydroxyphenyl ester(1), trigallic acid(2), 1, 2, 3, 4, 6-penta-O-galloyl-β-D-glucose(3), shikimic acid(4), gallic acid(5), methyl gallate(6)and ethyl gallate(7). Among them, compound 1 was a novel compound, and compound 2 was firstly isolated from the Galla Chinensis. The inhibition tests of the constituents showed that compound 3 exhibited in vitro antiviral activity against HSV-1 and RSV A strain, RSV Long strain with IC50 values of 13. 3, 3. 3, 3. 3 mmol/L, respectively.
