Advances in soluble guanylate cyclase stimulator
10.11665/j.issn.1000-5048.20160504
- VernacularTitle:可溶性鸟苷酸环化酶激动剂的研究进展
- Author:
Liqing HU
1
;
Rui YI
;
Qianbin LI
Author Information
1. 中南大学药学院药物化学系
- Publication Type:Journal Article
- Keywords:
soluble guanylate cyclase(sGC);
sGC stimulators;
mechanism of action;
signaling pathway;
riociguat
- From:
Journal of China Pharmaceutical University
2016;47(5):531-536
- CountryChina
- Language:Chinese
-
Abstract:
Soluble guanylate cyclase is a key signal transduction enzyme in the body, which can activate the NO-sGC-cGMP signaling pathway and inhibit the TGF-β signaling pathway. cGMP is one of the most important second messengers and also involved in a series of physiological or pathological responses including vasodilation, inhibition of platelet aggregation, inhibition of cell proliferation and so on. When TGF-β signaling pathway is inhibited, it can inhibit issue fibrosis and cell proliferation. Recent studies have shown that sGC can be activated directly to treat a variety of diseases. As a new class of potential drugs, sGC stimulators have shown many unique advantages. Herein, the mechanism and the latest research progress of sGC stimulators are reviewed, which could provide a useful information for further research of sGC stimulators.
