Advances of the uricosuric drugs
10.11665/j.issn.1000-5048.20160417
- VernacularTitle:促尿酸排泄药物研究进展
- Author:
Guilin YAO
1
;
Haiyong WANG
;
Tao LU
Author Information
1. 中国药科大学理学院有机化学教研室；湘北威尔曼制药股份有限公司研发中心
- Publication Type:Journal Article
- Keywords:
uricosuric;
mechanisms;
advances
- From:
Journal of China Pharmaceutical University
2016;47(4):491-496
- CountryChina
- Language:Chinese
-
Abstract:
Promoting uric acid excretion is an important approach for the treatment of gout and hyperuricemia. There are two main approaches included in the mechanism: one is inhibiting the function of renal tubular uric acid transporter to reduce the absorption of uric acid, and promoting excretion; the other is using uricase to catalyze the oxidation of uric acid to a more water-soluble allantoin that can also increase excretion. The mechanisms and progress of the uricosuric drugs are reviewed in this paper, providing reference for the further research and development.
