Anticomplementary effects of the extracts of five Verbenaceae herbs in vitro
10.11665/j.issn.1000-5048.20160413
- VernacularTitle:5种马鞭草科药用植物的抗补体活性
- Author:
Yang JIAO
1
;
Luhui ZOU
;
Li QIU
;
Yunfeng XIE
;
Yan LUO
;
Jizhao XIE
Author Information
1. 广西医科大学药学院
- Publication Type:Journal Article
- Keywords:
Verbenaceae;
Clerodendrum fortunatum L.;
Clerodendrum japonicum(Thunb.)Sweet;
Clerodendrum philippinum Schauer var.simplex Moldenke;
Callicarpa longissima(Hemsl.)Merr.;
Pygmaeopremna herbacea;
anticomplementary effect
- From:
Journal of China Pharmaceutical University
2016;47(4):469-473
- CountryChina
- Language:Chinese
-
Abstract:
The inhibition effects of the extracts of five Verbenaceae herbs, Clerodendrum fortunatum L. , Clerodendrum japonicum(Thunb. )Sweet, Clerodendrum philippinum Schauer var. simplex Moldenke, Callicarpa longissima(Hemsl. )Merr. and Pygmaeopremna herbacea, were investigated by cell hemolysis model in vitro on classical and alternative complement activation pathways. The water extracts of Pygmaeopremna herbacea, the water extract and the ethanol extract of Clerodendrum fortunatum L. , the water extract and the ethanol extract of Callicarpa longissima(Hemsl. )Merr. , the ethanol extracts of Clerodendrum japonicum(Thunb. )Sweet and Clerodendrum philippinum Schauer var. simplex Moldenke showed inhibition cell hemolysis effects on the classical pathway. Their CH50 values were 0. 092±0. 008, 0. 074±0. 008, 0. 088±0. 006, 0. 134±0. 017, 0. 123±0. 010, 0. 380±0. 080, and 0. 200±0. 015 g/L, respectively. The water extracts of Pygmaeopremna herbacea and Callicarpa longissima(Hemsl. )Merr. and the ethanol extract of Clerodendrum fortunatum L. showed inhibition cell hemolysis effects on alternative pathway. Their AP50 values were 0. 533±0. 033, 0. 758±0. 031, and 0. 362±0. 029 g/L, respectively. Five Verbenaceae herbs appear good anticomplementary effects in vitro. The ethanol extract of Clerodendrum fortunatum L. showed the best inhibitory activity.
