Effect of solvents on the formation thermodynamics of baicalein-nicotinamide cocrystals
10.11665/j.issn.1000-5048.20160408
- VernacularTitle:溶剂对黄芩素-烟酰胺共晶形成热力学的影响
- Author:
Yujie FAN
1
;
Yiting SONG
;
Yaqi ZHANG
;
Shuai QIAN
;
Yuanfeng WEI
;
Jianjun ZHANG
Author Information
1. 中国药科大学药剂学教研室
- Publication Type:Journal Article
- Keywords:
cocrystal;
baicalein;
nicotinamide;
solvent;
thermodynamics;
ternary phase diagrams
- From:
Journal of China Pharmaceutical University
2016;47(4):437-441
- CountryChina
- Language:Chinese
-
Abstract:
The purpose of this study was to investigate the formation thermodynamics of baicalein(BE)-nicotinamide(NCT)cocrystals in three solvents including ethyl acetate, acetone and trichloromethane. The solubilities of BE, NCT and BE-NCT in the above solvents at 25 °C were measured. Ternary phase diagrams(TPDs)of the BE-NCT-solvent systems were established. The non-linear fitting equation according to 1 ∶1 complexation mechanism of BE-NCT cocrystals demonstrated a good correlation between calculated and experiment data. ΔG0< 0 suggested that BE-NCT cocrystal formation was a spontaneous process. Among the organic solvents studied, the absolute value of ΔG0 in trichloromethane was significantly lower than that in the other two solvents. In addition, the cocrystallization zone in trichloromethane was far away from stoichiometric line. This study provides a theoretical foundation for solvent selection and preparation-condition optimization of BE-NCT cocrystals.
