Advances in cancer photodynamic therapy
10.11665/j.issn.1000-5048.20160403
- VernacularTitle:肿瘤的光动力治疗研究进展
- Author:
Hong DONG
1
;
Ruixue WU
;
Jiaqi LIU
;
Qing HUANG
;
Ya ZHOU
;
Yiqiao HU
Author Information
1. 南京大学医学院
- Publication Type:Journal Article
- Keywords:
tumor;
photodynamic therapy;
penetration depth;
oxygen;
activatable photodynamic;
advances
- From:
Journal of China Pharmaceutical University
2016;47(4):377-387
- CountryChina
- Language:Chinese
-
Abstract:
Abstract:Photodynamic therapy(PDT)is a minimal invasive therapy that have been clinically approved for the cancer treatment with selective cell toxicity. When activated by appropriate wavelength of light, photosensitizers transfer the absorbed photon energy to the surrounding molecular oxygen to generate reactive oxygen species, which result in cell death, vessel damage and immune activation of tumor site. This paper summarize the main challenges and recent solutions for PDT application, such as the low tissue penetration of light, toxicity induced by nonspecific accumulation of skin and poor PDT effect of hypoxia tumor.
