Protective effects of Jinqi Jiangtang tablets on diabetic complications of cardiovascular diseases in Drosophila
10.11665/j.issn.1000-5048.20160317
- VernacularTitle:金芪降糖片对糖尿病心血管并发症的治疗作用
- Author:
Youhong ZHAO
1
;
Yang YANG
;
Zhishen XIE
;
Xiaojun XU
;
Li LIU
Author Information
1. 南京医科大学第一附属医院
- Publication Type:Journal Article
- Keywords:
Jinqi Jiangtang tablets;
Drosophila;
diabetic complications of cardiovascular diseases;
glucose and lipid metabolism;
mTOR/4EBP
- From:
Journal of China Pharmaceutical University
2016;47(3):348-352
- CountryChina
- Language:Chinese
-
Abstract:
This study was to investigate the protective effects of Jinqi Jiangtang tablets on diabetic complications of cardiovascular disease in Drosophila. The effects of Jinqi Jiangtang tablets on hypolipidemia and hypoglycemia by high fat diet(HFD)induced model organism Drosophila with the content of triglyceride and trehalose in Drosophila as indexes, were investigated. And the Drosophila heart function was detected by high speed EM-CCD; cell signaling pathways were detected by Western blot and RT-PCR. The results showed that high fat diet could induce the appearance of hyperglycemia and hyperlipidemia on Drosophila model. Jinqi Jiangtang tablets could significantly reduce triglyceride and trehalose and protect heart function of Drosophila induced by high fat diet. Jinqi Jiangtang tablets could also increase the expression of 4ebp mRNA, while decreasing p-4EBP protein and pepck mRNA expression. This study demonstrated that Jinqi Jiangtang tablets have a protective effect on HFD-induced dyslipidemic-diabetic and cardiac dysfunction, which may be related to mTOR/4EBP pathway.
