Hypoglycemic effects of terpenes from Fructus Corni on db/db diabetic mice
10.11665/j.issn.1000-5048.20160315
- VernacularTitle:山茱萸总萜对db/db糖尿病小鼠的降血糖作用
- Author:
Zhimeng XU
1
;
Jingjing ZHU
;
Zhenzhou JIANG
;
Fengchang LOU
;
Tao WANG
Author Information
1. 中国药科大学江苏省新药筛选重点实验室
- Publication Type:Journal Article
- Keywords:
terpenes from Fructus Corni;
diabetes;
db/db mice;
hypoglycemic effect
- From:
Journal of China Pharmaceutical University
2016;47(3):337-341
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the hypoglycemic effects of terpenes from Fructus Corni(TFC)on type 2 diabetes mellitus, the db/db diabetic mice were intragastrically administered with 25, 50, 100 mg/kg of TFC for 10 weeks. The fasting blood glucose, insulin(Ins), glycosylated serum protein(GSP), total cholesterol(TC)and triglyceride(TG)levels were determined. At weeks 8 and 10, intraperitoneal injections of glucose and gavage starch tolerance tests were performed, respectively. The db/db mice showed obvious obesity. Each dose of TFC could significantly reduce the body weight of db/db mice(P< 0. 05). After 4 weeks of administration, all doses of TFC significantly reduced the fasting blood glucose of db/db mice(P< 0. 05). The serum TC, TG levels were also significantly decreased in the TFC middle- and high-dose groups(P< 0. 05). In addition, middle- and high-dose of TFC could significantly reduce the level of GSP. Middle- and high-dose of TFC also significantly improve the glucose tolerance and gavage starch tolerance in db/db mice(P< 0. 05). These results suggest that TFC could improve diabetes-related symptoms via regulating glucose and lipids metabolism.
